Immunology of neuropsychiatric disorders
STRESS IMMUNOLOGY GROUP, PUCRS. Porto Alegre, RS
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Principal Investigators: Moisés E. Bauer and Rodrigo Grassi-Oliveira
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Interests: the impact of stress (current and past) on inflammatory, cognitive, epigenetic, neuroendocrine, and early-senescence markers in neuropsychiatric diseases and drug addiction.
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Subjects: human samples (healthy, bipolar disorder, schizophrenia, major depression, breast cancer, crack and arthritis); experimental models (C57/BL6 and Balb/C mice).
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Methodologies:
- Psychological assessments: cognitive functioning; stress-related behavioral responses (animal & human); Trier social stress test (TSST);
- ELISAs: neurotrophins, salivary and hair cortisol;
- FACS: immunophenotyping, cytokines, cell signaling (MAPK and NF-kB);
- PCR and qPCR: stress-related micro RNAs, methylation and histone modifications, telomere size and genetic polymorphisms.
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Contact: bauer.moises@gmail.com
RESEARCH GROUP IN BEHAVORAL AND MOLECULAR NEUROSCIENCE OF BIPOLAR DISORDER, UNIFESP, São Paulo, PS
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Principal Investigators: Elisa Brietzke
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Interests: the impact of stress (current and past) on inflammatory, cognitive, epigenetic, neuroendocrine, and early-senescence markers in neuropsychiatric diseases and drug addiction.
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Subjects: human samples (healthy, bipolar disorder, schizophrenia, major depression); experimental models.
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Methodologies:
- Psychological assessments: cognitive functioning;
- ELISAs: neurotrophins, salivary and hair cortisol;
- FACS: immunophenotyping, cytokines;
- PCR and qPCR: telomere lenght, immunogenetics, RNA splicing;
- Metabolomics and proteomics: H+ MRN, chemometric analysis.
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Contact: elisabrietzke@hotmail.com
IMMUNOLOGY OF PSYCHIATRIC DISORDERS, UFMG, Belo Horizonte, MG
Principal Investigators: Izabela Guimarães Barbosa e Antônio Lúcio Teixeira
Interests: The investigation of immunology in the neurobiology of severe psychiatric disorders (major depressive disorder, schizophrenia, bipolar disorder, and obsessive-compulsive disorder) and its relationships between psychiatric, cognitive and metabolic comorbidities
Subjects: Human samples ((healthy, bipolar disorder, schizophrenia, major depressive disorder, obsessive compulsive disorder); experimental models (rats and mice).
Methodologies:
- Psychological assessments (animal & human): cognitive functioning; stress-related behavioral responses;
- Neuroimmaging exams.
- ELISAs and Multiplex: neurotrophins, cytokines, inflammatory markers, salivary and hair cortisol;
- FACS: immunophenotyping, cytokines, cell signaling (MAPK and NF-kB);
- PCR and qPCR: stress-related mRNAs, and genetic polymorphisms.
- cell culture: primary and lineage cells.
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Contact: izabelagb@gmail.com