Immunology of neuropsychiatric disorders

STRESS IMMUNOLOGY GROUP, PUCRS. Porto Alegre, RS

Principal Investigators: Moisés E. Bauer and Rodrigo Grassi-Oliveira

Interests: the impact of stress (current and past) on inflammatory, cognitive, epigenetic, neuroendocrine, and early-senescence markers in neuropsychiatric diseases and drug addiction.

Subjects: human samples (healthy, bipolar disorder, schizophrenia, major depression, breast cancer, crack and arthritis);  experimental models (C57/BL6 and Balb/C mice).

Methodologies:

- Psychological assessments: cognitive functioning; stress-related behavioral responses (animal & human); Trier social stress test (TSST);

- ELISAs: neurotrophins, salivary and hair cortisol;

- FACS: immunophenotyping, cytokines, cell signaling (MAPK and NF-kB);

- PCR and qPCR: stress-related micro RNAs, methylation and histone modifications, telomere size and genetic polymorphisms. 

Contact: bauer.moises@gmail.com

RESEARCH GROUP IN BEHAVORAL AND MOLECULAR NEUROSCIENCE OF BIPOLAR DISORDER, UNIFESP, São Paulo, PS

Principal Investigators: Elisa Brietzke

Interests: the impact of stress (current and past) on inflammatory, cognitive, epigenetic, neuroendocrine, and early-senescence markers in neuropsychiatric diseases and drug addiction.

Subjects: human samples (healthy, bipolar disorder, schizophrenia, major depression);  experimental models.

Methodologies:

- Psychological assessments: cognitive functioning;

- ELISAs: neurotrophins, salivary and hair cortisol;

- FACS: immunophenotyping, cytokines;

- PCR and qPCR:  telomere lenght, immunogenetics, RNA splicing;

- Metabolomics and proteomics: H+ MRN, chemometric analysis.

Contact: elisabrietzke@hotmail.com

IMMUNOLOGY OF PSYCHIATRIC DISORDERS, UFMG, Belo Horizonte, MG

 

Principal Investigators: Izabela Guimarães Barbosa e Antônio Lúcio Teixeira

 

Interests: The investigation of immunology in the neurobiology of severe psychiatric disorders (major depressive disorder, schizophrenia, bipolar disorder, and obsessive-compulsive disorder) and its relationships between psychiatric, cognitive and metabolic comorbidities

 

Subjects: Human samples ((healthy, bipolar disorder, schizophrenia, major depressive disorder, obsessive compulsive disorder);  experimental models (rats and mice). 

 

Methodologies

- Psychological assessments  (animal & human): cognitive functioning; stress-related behavioral responses; 

- Neuroimmaging exams.

- ELISAs and Multiplex: neurotrophins, cytokines, inflammatory markers, salivary and hair cortisol;

- FACS: immunophenotyping, cytokines, cell signaling (MAPK and NF-kB);

- PCR and qPCR: stress-related mRNAs, and genetic polymorphisms.

- cell culture: primary and lineage cells.

Contactizabelagb@gmail.com